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We report a patient who,at age 38,presented with temporal lobe seizures and an atypical memory disorder 3 years before the discovery of a testicular tumor.Detailed neuropsychological testing revealed a relatively isolated amnesic syndrome.The amnesia was atypical as the patient could retain information for hour-long periods,only to lose it later.Serologic studies revealed the presence of a circulating autoantibody that demonstrated an unusual affinity for the nucleolus of cerebral cortical neurons.Western blot analysis of cortical neurons revealed that this antibody reacted with proteins different from other previously identified paraneoplastic neurologic antigens(Hu,Yo,Ri).We believe this to be the case of paraneoplastic limbic encephalitis secondary to the testicular tumor.This patient presents unique characteristics with respect to the mode of presentation,features of the amnesia,and the presence of a circulating antibody with an unusual reactivity pattern. |
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amnesia
autoantibodies
carcinoma of testis
limbic encephalitis
memory,impairment of
MRI,abnormal
remote effect of cancer on the nervous system
seizure
seizure,psychomotor-temporal lobe
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